The effect of stain on platelet
(1) The role that Rab27 plays in platelet function
(2) Post-translational prenylation of Rab27 and how this can be pharmacologically inhibited by statins and other drugs (such as bisphosphonates)
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(3) Do platelets synthesise protein (particularly Rabs such as Rab27b)? Why is this important for the possibility that statins inhibit prenylation in platelets?
Within this, it also should describe how inhibition of prenylation by statins etc. can be detected
the approaches using are described in the literature This should also include details of the most appropriate incubation conditions for platelets
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